Hello,
Yes you can use the pooled Capacity with setup matrix.
As standard, a pool capacity with several individual capacities, or one capacity that can be used by several operations, is mapped to a multiactivity resource. Individual capacities without this indicator are mapped to single-activity resources.
Please refer useful help link,
Integration of Resources - Integration of SAP APO and SAP R/3 - SAP Library
Best Regards,
R.Brahmankar